Omeprazole
Omeprazole: Availability: i. Rolling capsule 20 mg contain coated pellets of Omeprazole 20mg. ii. Rolling capsule 20 mg contain coated pellets of Omeprazole 40mg Function and action: Omeprazole a substituted benzimidazole is a proton pump inhibitor that inhibits gastric acid secretion. It is an antisecretory compound the substituted benzimidazole that does not exhibit anticholinergic or histamine properties. Its stops secretion of gastric acid by blocking the enzyme system. Metabolism: Omeprazole is completely metabolized in the liver. Peak plasma concentration (PPP) 40mg achieved in 0.5 to 3.5 hours. Absorption of Omeprazole is not affected by food and also appears to be dose-dependent. The systematic bioavailability of omeprazole is approximately 35%. After repeated once daily dose the bioavailability increased to about 60%. Elimination and Excretion: Following absorption of Omeprazole is almost completely metabolized in the liver. The majority of dose about 77% in urine