Perispa, Eperisone HCL


Perispa
Eperisone HCL
Tablets
Composition
Each sugar coated tablet coatis;
Eprisone hydrochloride (Platinum Specs)..............50mg
Product complies Platinum specs
DESCRIPTIONS:
Generic name; Eperisone hydrochloride
Chemical name; 4 Ethyl-2 methyl-3 piperidinoropiophenone hydrochloride
INDICATIONS:
Spastic paralysis in the following diseases.
Cerebrovascular disease-specific spinal paralysis cervical spondylolysis, postoperative sequelae ( including cerebrospinal tor), sequelae to trauma(spinal trauma head injury), amyotrophic lateral sclerosis, cerebral palsy, spinocerebellar degeneration, spinal, vascular diseases and other encethalomyelopathies.
Improvement of muscular hypertonic symptoms in the following diseases.
Cervical syndrome, teriarphritis of the shoulder, lumbago.
DOSAGES AND ADMINISTRATION
The usual adult dosage for oral use is one tablet three times a day after each meal or as directed by the physician. The dosage should be adjusted depending on the patient age and severity of symptoms.
USAGE DURING PREGNANCY, DELIVERY, AND LACTATION
Safety for use in pregnancy has not been established. Perispa should only be used in pregnant women or women suspected of being pregnant. If therapeutic benefits are evaluated to outweigh the possible risk of treatment.
It is recommended that this drug not be used during lactation. If it must be used at such times, the patients should this continue breastfeeding during treatment.
PEDIATRIC USE
Safe use of Perispa in children has not been definitely established.
     USE IN THE ELDERLY
Since the elderly patients often have psychological hypofunction, it is advisable to take measures, such as the reduction in dosages under careful supervision.
PHARMACOKINETICS
The pharmacokinetics properties of Eperisone hydrochloride after a single dose of 150 mg/day orally for 14 consequent days to 8 healthy adult male volunteers.
Elimination half-life; 1.6 to 1.8 hr.
Aria under the plasma concentration-time curve (AUC): 19.7 to 21.1 ng hr/ml
The plasma concentration profiles of Eperisone hydrochloride determined at day 8 and day 14 with not significantly vary from those of the first day.
PHARMACOLOGY
          Skeletal muscle relaxation
          Relaxation of hypertonic skeletal muscles
          Improves intramuscular blood flow
          Suppression of spinal reflex potential
          Reduction of the muscle spindle sensitivity
          Via-motor neurons
          Vasodilatation and augmentation of blood flow
          Analgesic action and inhibition of the pain reflex in the spinal cord.
Efficacy;
[ Data-based on the assessment of 8660 clinical reports of aperisone hydrochloride usage-Oct 1982 to Sept 1986].
Symptom Rate of improvement[    ]
.        Rigidity 70.2
.        Stiffness 70.4
.        Dizziness 77.4
.        Headache 78.9
.        Tinnitus 65.9
.        Cervical pain 71.6
.        Stiff shoulder 82.1
.        Lumbago 74.8
.        Difficulty in going up and downstairs 55.2
.        Difficulty in walking 56.5
          CONTRAINDICATION;
Patients with a history of hypersensitivity to any ingredients of the drug.
PRECAUTIONS
Careful administration [ Perispa should be administered with care in the following patients ];
Patients with a history of drug hypersensitivity.
Patients with hepatic function disorder.
Important precautions; weakness, light-headedness, sleepiness or other symptoms may occur.
In the event of such symptoms, the dosage should be reduced or treatment discontinued. Patients should be cautioned against engaging in potentially hazardous activities requiring alertness. Such as operating machinery or driving a car.
SIDE EFFECTS
The side effects of Perispa are very rare. Only a few cases have been observed and none of them were of serious nature clinically. The observed side effects excessive relaxation, stomachache, nausea, vertigo, anorexia, drowsiness, skin rashes, diarrhea, indigestion, Gl disturbances, insomnia, headache, constipation, etc.
DREG INTERACTIONS
There is a report that disturbances in ocular accommodation occurred after the concomitant use of tolperisone hydrochloride and methocarbamol.
STORAGE INSTRUCTIONS
Store blew 30’C in a dry place. Protect from light. Keep out of the reach of children.
PRESENTATION
Box of 3=10 tablets in all bilister pack.  




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